Biomarkers in Hematology and Oncology
A cancer biomarker refers to a substance which indicates the presence of cancer in the body and are particularly associated with genetic mutations or epigenetic alterations which determine whether the individuals are susceptible to particular type of cancers or not. Some of the potentially predictive cancer biomarkers include KRAS, p53, EGFR, erbB2 for colorectal, esophageal, liver and pancreatic cancer. Mutations of genes such as BRCA1 and BRCA2 are for breast and ovarian cancer. Abnormal methylation of tumour suppressor genes like p16, CDKN2B, and p14ARF are mostly for brain cancer. Hypermethylation of MYOD1, CDH1, and CDH13 is for cervical cancer and hyper methylation of p16, p14, and RB1 is for oral cancer. Therefore, these kinds of biomarkers can be assayed non-invasively by using collected biofluids like blood or serum.
- Track 1-1 Genetic markers
- Track 2-2 Diagnostic Biomarker
- Track 3-3 Biomarker Discovery
- Track 4-4 Tumor Markers
- Track 5-5 Cancer biomarkers